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Environmental Triggers Factors like stress, infections, or physical trauma can trigger flare-ups in people who are genetically at risk

For example, the current recommendations for the management of children with Kawasaki disease include treatment with high-dose aspirin in the acute phase, and low-dose aspirin during the period of thrombocytosis

Cell Communication and Signaling, 21 , Article 67

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Approved by FDA in 1997, hydroxyurea, a ribonucleotide reductase inhibitor, can induce fetal Hb production (Schechter, 2008)

Both are crucial for neutralizing ROS and protecting cells from damage